Primary Skeletal Muscle Non-Hodgkin’s Lymphoma in the Thigh: A Case Report

Primary skeletal muscle non-Hodgkin’s lymphoma (PSMNHL) is a rare tumor accounting for only 0.1% of all lymphoma. We managed a case of extra-nodal primary lymphoma in right thigh exclusively with chemotherapy. A 46 year old male was referred to our center with progressively increasing mass in the anterior part of right thigh since 2 months. After proper evaluation biopsy was obtained from the mass and sent for histopathological analysis. It demonstrated a diffuse proliferation of large lymphoid cells. Immunohistochemistry examination confirmed diagnosis of NHL of skeletal muscle. We managed case with chemotherapy therapeutic approach Selective chemotherapy was administered with RCHOP (Rituximab, Cyclophosphamide, hydroxydaunomyocin, oncovin, prednisone) 6 cycle regimen. Complete radiological response was achieved after 3 cycles. Now 4 years after completing treatment he is in a state of excellent general condition without evidence of local or distant recurrence. We reported a case of PSMNHL in thigh in middle aged man with purpose of emphasizing role of intelligent diagnostic work up with radiological imaging, histopathology and immunohistochemistry techniques. Chemotherapy with RCHOP regimen with regular follow up to exclude local and distant recurrence has been resulted in good general health of the patient.

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