Triple Negative Breast Cancer- Overview of of Therapeutic Options

Triple negative breast cancer (TNBC) is a heterogeneous phenotype of breast cancer characterized by the absence of estrogen receptor, progesterone receptor and overexpression of human epidermal growth factor receptor 2 (HER2) gene. In comparison to other subtypes of breast cancer, TNBCs are distinctly aggressive in nature with higher rate of recurrence and short overall survival (OS) among patients with metastasis. It presents with different clinical profile from other subtypes. Major hurdle in TNBC is its vast intertumor and intra-tumor heterogenecity and failure to identify a single unifying targetable alteration.

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